Lofexidine Detox: The New Non-Opioid Drug for Opioid Withdrawal

Opioids are among the most dangerous substances readily available to abuse. From the damage it does to your body and brain to the far-reaching results of chronic opioid abuse, opioids have been the spotlight in the past years. Research shows that within a span of a decade, opioids alone were already the cause of 15,000 deaths a year in the United States, and that number has more than doubled up to 30,000 and higher.

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With these numbers in mind, researchers, doctors, and scientists work around-the-clock to combat this wave of opioid abuse and addiction. Very recently, the U.S. Food and Drug Administration (FDA) approved the use of a new type of drug to help addicts treat their opioid addiction. Lucemyra (lofexidine hydrochloride) works to lessen the intensity of withdrawal symptoms and, although it is effective, lofexidine should only be used with caution and doctor’s approval/supervision.

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How to Treat Opioid Withdrawal

As some of the most chemically-altering drugs for the brain, opioid abuse commonly leads to addiction. In treating opioid addiction, it is more than likely that the patient experiences withdrawal symptoms. Withdrawal symptoms are the result of an addict’s brain practically relying on a drug for its source of dopamine. In treatment, a patient is denied that drug and thus the body reacts and readjusts to sobriety.

Common withdrawal symptoms associated with opioids can include, but are not limited to:

  • Anxiety
  • Runny noses
  • Irritability
  • Nausea
  • Sweating
  • Cravings
  • Muscle aches/cramps
  • Vomiting
  • Sleep irregularities

Opioids themselves are common medications used to treat other opioid addictions. Buprenorphine and methadone are both opioid agonists, binding to opioid receptors and making the user experience the similar, yet much more subtle effects of abusing opioids. This quality makes opioids a valid medication used in treatment for opioid addiction, but it also raises some questions. Isn’t use of other opioids to treat addiction simply replacing the addiction with a different one?

This question is common among those seeking information about drug treatment, and rightfully so. While it is true that medications used in medication-assisted treatment (MAT) can be harmful and addictive, this is rarely the case; doctors and other medical experts are trained to only administer safe amounts of medication in MAT. Even so, the stigma of MAT for opioid abuse disorder exists.

Fortunately, lofexidine is the first non-opioid drug used in opioid withdrawal. Lofexidine detox removes the stigma surrounding the use of opioids in treating opioid addiction and is very effective in doing so.

Darvocet Withdrawal

Safe Use of Lofexidine

As mentioned before, taking lofexidine only as instructed is instrumental in preventing negative side effects. Lofexidine comes in tablets, either coated with a film or as a tan, round tablet. Oral consumption is the safest method of taking lofexidine and should only be used to help treat adults (not enough research has been done yet to determine its safety with youth or elderly.)

According to Medicines.org, safe dosage amounts start at 0.8 mg per day, increasing as days go on by 0.4 mg per day. It is important to not exceed 2.4 mg in one day, and single dose amounts should not exceed 0.8 mg. A high-quality treatment center makes sure that each and every case of opioid addiction is viewed as unique, and your doctors will determine your dose amount depending on your severity and length of addiction.

Adverse Effects of Lofexidine

While a number of medications are used to treat opioid addiction, the ways that they affect the users vary. For example, naltrexone is a medication commonly used in medication-assisted treatment for opioid abuse disorder. It binds to and blocks opioid receptors, speeding up the detoxification process and pretty much sending the user into immediate withdrawal. 

Some people do not like the way that naltrexone affects them, and lofexidine is a great alternative. Instead of sending the user into immediate withdrawal and trying to speed up detox, lofexidine mitigates the chills, sweating, cramps, and runny nose symptoms of opioid withdrawal and detox.

Unfortunately, as is the case with every other medication used in addiction treatment, lofexidine and lofexidine detox can inadvertently cause a number of adverse effects, such as:

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  • Irregularities in heart rate
  • Nausea
  • Dizziness
  • Fatigue
  • QT prolongation (increased risk of an irregular heartbeat)

Irregularities in blood pressure are common when it comes to lofexidine use, as lofexidine was originally used to treat high blood pressure. When using lofexidine, a user may experience low blood pressure, and when intake is ceased (after roughly 14 days of use), the user’s blood pressure will “bounce back,” often resulting in high blood pressure.

To best avoid the adverse effects of lofexidine, it should be used as a short-term medication aiding in the tapering off of an opioid. Tapering refers to the substitution of an addicted opioid by a new medication, then the gradual reduction of that new medication until the patient is able to function normally without any substance in his or her system.

Seeking Treatment

With this new non-opioid medication for opioid addiction treatment, the FDA and the addiction treatment community as a whole are taking substantial steps in battling this opioid epidemic. Our mission is your mission: to eliminate any dependency on a drug and prevent future relapse and addictions.

Here at New Perspectives, we understand how difficult and destructive drug addiction can be, opioids especially. Through Lofexidine detox, we make treating opioid abuse disorder and opioid addiction a breeze. Call us today at (855)-463-0793 and let one of our 24/7 specialists answer any and every question you may have regarding addiction, addiction treatment, and countless other topics relating to substance abuse.